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Obliterating endarteritis of the vasa vasorum results in ischemia and weakening of the aortic adventitia, which may lead to aneurysm formation in the thoracic aorta.
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In the largest vessels, the vasa vasorum penetrates the outer (tunica adventitia) layer and middle (tunica media) layer almost to the inner (tunica intima) layer.
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Arteritis of the vasa nervorum leads to mononeuritis multiplex or polyneuropathy.
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Other species, such as dogs, do have vasa vasorum below their renal vasculature, and aneurysms at this site are substantially less likely.
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The third stage of syphilis also manifests as aneurysm of the aorta, which is due to loss of the vasa vasorum in the tunica adventitia.
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