Auf welchem Wege der Phänotyp durch Hintergrundgene moduliert wird, ist Gegenstand laufender Studien.
Die Mutanten spasmodic und oscillator tragen pathologische Glra1-Allele.
Diese Mausstämme stellen ein wichtiges Modell zur Untersuchung der glycinergen Funktion in vivo dar und dienen als Therapiesysteme für den neuronenspezifischen Gentransfer.
www.biochem.uni-erlangen.deIn contrast, GlyT2 knockout mice are normal at birth but develop a complex neuromotor phenotype including spastic seizures, spontaneous tremors, and an impaired righting response leading subsequently to their death during the third postnatal week.
Extensive biochemical and immunhistological analysis failed to reveal abnormalities in mutant animals.
Electrophysiological studies demonstrate reduced amplitudes in mIPSC.
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