Spezifische Kontakte gibt es zu Guanosinen : die Threonin-Seitenketten bilden Wasserstoffbrücken zu den Guaninen neben dem Phenoxazon.
Obwohl die DNA-Sequenz nicht die von Actinomycin bevorzugte GC-Interkalationsstelle enthält, wird die Bindungsstelle durch das Ausschwenken der Adenine und Thymine in den Einzelstrangbereichen simuliert.
www.biologie.uni-hamburg.deThere are specific contacts to guanosines : the sidechain threonines are hydrogen bonded to the guanines sandwiching the penoxazone.
So although the DNA sequence displays no GC step as intercalation site, the " canonical " site is mimicked by diverting the adenine and thymine in the single stranded region.
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