Eines unserer Projekte zielt daher darauf ab, die Allelfrequenz struktureller Varianten in heterogenem Tumorgewebe zu schätzen.
Neben Genotypen und Allelfrequenzen ist die Kenntnis der einzelnen Haplotypen von großem Interesse.
Deshalb entwickeln wir Algorithmen zur Rekonstruktion der Haplotypen von diploiden Organismen sowie von Viruspopulationen in einem Wirt.
www.zbi.uni-saarland.deOne of our projects therefore aims at estimating the allele frequency of structural variations in heterogenous tumor tissue.
Beyond genotypes and allele frequencies, the knowledge of the individual haplotypes is of great interest.
Therefore, we develop algorithms to reconstruct haplotypes in diploid organism and within-host virus populations.
www.zbi.uni-saarland.dePopulationsgenetik
Die Populationsgenetik beschäftigt sich mit der Veränderung von Allelfrequenzen innerhalb des Genpools einer Art.
Die Fragestellungen sind dabei verschiedener Natur.
www.biologie.uni-regensburg.dePopulation Genetics
Population genetics is the study of changes of allele frequencies within the gene pool of a species as a whole and its constituent populations.
The addressed questions can be diverse.
www.biologie.uni-regensburg.deSchlötterer dazu :
„ PoPoolation2 hilft uns dabei, Allelfrequenzen bei verschiedenen Populationen zu vergleichen.
Damit können wir schnell und kostengünstig analysieren, wie sich Populationen verschiedener Arten genetisch an ihre jeweilige Umwelt angepasst haben.
www.vetmeduni.ac.atThe program has been tested on the sequences of a single chromosome from two distinct populations of the fruit fly Drosophila melanogaster and the results confirm that the program can correctly predict the levels of divergence between the samples.
As Schlötterer says, “ PoPoolation2 helps us compare the allele frequencies between populations.
It will enable us quickly and cheaply to compare how populations of different species have adapted differently to their environments, giving us better information on the big picture of evolution in practice. ”
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