It produces far stronger inhibition of the PDE 6 present in the retina than sildenafil.
Toxicological concerns also exist for other reasons, including the potential for alkylating compounds to arise through metabolism, such as happens with chlorodenafil (VENHUIS, B.J., de KASTE, D.:
J. Pharm. Biomed.
www.arznei-telegramm.deEs hemmt das in der Retina vorkommende PDE 6 deutlich stärker als Sildenafil.
Toxikologische Bedenken bestehen unter anderem auch wegen potenziell bei der Verstoffwechselung entstehender alkylierender Verbindungen, beispielsweise bei Chlorodenafil (VENHUIS, B.J., De KASTE, D.:
J. Pharm. Biomed.
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