All matrilins have a similar modular composition with VWA and epidermal-growth-factor ( EGF ) like domains as well as a coiled-coil oligomerization domain.
Mutations in MATN3 lead to multiple epiphyseal dysplasia ( MED ) .
Collagen VI forms a distinct microfibrillar network in most forms of extracellular matrix that anchors interstitial structures.
www.uni-koeln.deOligomerisierungsdomäne.
Mutationen in MATN3 führen zu Multipler Epiphysärer Dysplasie (MED).
Kollagen VI formt ein ausgeprägtes mikrofibrilläres Netzwerk in fast allen Bindegeweben und verankert interstitielle Strukturen.
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