Dieser spezifische Proteinmangel führt zu einer veränderten Nervenzellaktivität, in deren Folge die Tiere schlechter lernen.
Experimentell lässt sich das Lerndefizit durch zusätzliche Homer-1-Mengen verhindern, was dieses Protein zu einem Schlüsselmolekül für die Entwicklung von Medikamenten gegen stressbedingte Lernschwäche macht.
Klaus Wagner, Wissenschaftler am Max-Planck-Institut für Psychiatrie, hat das Lernverhalten von Mäusen untersucht, nachdem diese stark gestresst wurden.
www.mpipsykl.mpg.deIn the experiments, it was possible to prevent the cognitive deficit by administering additional volumes of the protein to the mice.
This suggests that Homer-1 could turn into a key molecule for the development of drugs for the treatment of stress-induced cognitive deficits.
Klaus Wagner, scientist at the Max Planck Institute of Psychiatry, studied the learning behaviour of mice that had been subjected to severe stress.
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