Es bleibt jedoch unklar wie, z.B. die Anwesenheit eines strukturell intakten Golgi-Apparates die Signalweiterleitung innerhalb des MAPK Signalweges beeilflusst.
Durch gezielte Störung der morpho-funktionellen Organisation des Sekretionsweges in Kombination mit Bioinformatik ( anchored networks und Modeling von Signalwegen ), hoffen wir einen tieferen Einblick zu bekommen, wie die örtliche Regulation des MAPK-Weges funktioniert.
Signaling cascade
www.bitg.chHowever, it remains unclear to what extent, for instance the presence of a Golgi ribbon, is involved in signal propagation through the MAPK pathway.
By disrupting the morpho-functional organization of the secretory pathway in combination of modeling approaches ( anchored networks and modeling signaling pathways ), we hope to gain a deeper insight into spatial regulation of MAPK pathways.
Signaling cascade
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