Die Methylgruppen zwingen die AT-Paare, von den GC-Paaren wegzukippen.
In der misgepaarten DNA gibt es dagegen keine sterische Hinderung zwischen Methylgruppe und Base.
Literatur:
www.biologie.uni-hamburg.deThe methyl group forces the AT basepair to wedge away from the GC pair.
In the mismatched DNA there is no steric hindrance between the methyl group and the base.
Literature:
www.biologie.uni-hamburg.deYou can suggest improvements to this PONS entry here:
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