Such libraries are employed in functional screens for target- and biomarker identification for personalised tumour-therapy.
Using the ENTRACE technology the transcriptome of individual patients is converted into an shRNA library, including knockdown-constructs against splice variants, mutations and formerly unknown transcripts.
www.nmi.deSolche Bibliotheken dienen der Zielprotein- und Biomarker-Identifizierung für personalisierte Tumor-Therapien.
Durch die ENTRACE Technologie lässt sich das Transkriptom individueller Patienten in eine shRNA Bibliothek umwandeln, welche Knockdown-Konstrukte gegen Spleißvarianten, Mutationen und bislang unbekannte Transkripte einschließt.
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