Die Regulationsmechanismen waren jedoch nicht bekannt.
Wir konnten zeigen, dass mehrere microRNAs (miRNAs) des genomischen miR379-410 Clusters an die 3‘-untranslatierte Region von N-Cadherin binden und so die Expression dieses Zelladhäsionsmoleküls regulieren und feinjustieren.
www.ftn.uni-mainz.deThe exact regulatory mechanisms, however, were not known.
We could show that several microRNAs (miRNAs) of the genomic miR379-410 cluster bind directly to the N-cadherin 3'- untranslated region thereby fine-tuning the expression of this cell adhesion molecule.
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